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KMID : 0624620090420110697
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BMB Reports
2009 Volume.42 No. 11 p.697 ~ p.704
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Bioinformatic approaches for the structure and function of membrane proteins
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Nam Hyun-Jun
Jeon Jou-Hyun
Kim San-Guk
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Abstract
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Membrane proteins play important roles in the biology of the cell, including intercellular communication and molecular transport. Their well-established importance notwithstanding, the highresolution structures of membrane proteins remain elusive due to difficulties in protein expression, purification and crystallization. Thus, accurate prediction of membrane protein topology can increase the understanding of membrane protein function. Here, we provide a brief review of the diverse computational methods for predicting membrane protein structure and function, including recent progress and essential bioinformatics tools. Our hope is that this review will be instructive to users studying membrane protein biology in their choice of appropriate bioinformatics methods.
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KEYWORD
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Evolutionary approaches, Function prediction, Membrane protein, Protein structure, Topology prediction
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